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COVID19 has spread all over the globe with ARDS as the most grave complicating factor in its mortality and morbidity As there is not an effective anti-viral drug or an imminent vaccine against this virus we proposed a novel insight about cytokine storm-indiced ARDS in this disease and conducted an in silico study according to the pathophysiology of cytokine storm We found that losartan and imatinimay break the life cycle of the virus to the degree that its affinity to ACE2 may decline, the function of papin-like protease disrupts, and the cytokine storm may subside, as well This means that the death toll of the disease may decline sharply till a vaccine is produced in the near future All the results should be validated in subclinical studies br //div
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Are Losartan and ImatiniEffective Against SARS-CoV2 Pathogenesis? a Pathophysiologic-Based in Silico Study
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