kyzku88p | Knowledge4COVID-19

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?:abstract	Humoral immunity to the Severe Adult Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is not well understood but may be a crucial factor of immune protection. The possibility of antibody cross-reactivity between SARS-CoV-2 and other human coronaviruses (HCoVs) would have important implications for immune protection but also for the development of specific diagnostic ELISA tests. Using peptide microarrays, n=24 patient samples and n=12 control samples were screened for antibodies against the entire SARS-CoV-2 proteome as well as the Spike (S), Nucleocapsid (N), VME1 (V), R1ab, and Protein 3a (AP3A) of the HCoV strains SARS, MERS, UC43 and 229E. While widespread cross-reactivity was revealed across several immune dominant regions of S and N, IgG binding to several SARS-CoV-2-derived peptides provided statistically significant discrimination between COVID-19 patients and controls. Selected target peptides may serve as capture antigens for future, highly COVID-19-specific diagnostic antibody tests.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/kyzku88p_hasAnnotation_C0057686> <https://research.tib.eu/covid-19/entity/kyzku88p_hasAnnotation_C0206422> <https://research.tib.eu/covid-19/entity/kyzku88p_hasAnnotation_C4698070> <https://research.tib.eu/covid-19/entity/kyzku88p_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Holenya%2C_P.%3B_Lange%2C_P._J.%3B_Reimer%2C_U.%3B_Woltersdorf%2C_W.%3B_Panterodt%2C_T.%3B_Glas%2C_M.%3B_Wasner%2C_M.%3B_Eckey%2C_M.%3B_Drosch%2C_M.%3B_Hollidt%2C_J.-M.%3B_Naumann%2C_M.%3B_Kern%2C_F.%3B_Wenschuh%2C_H.%3B_Lange%2C_R.%3B_Schnatbaum%2C_K.%3B_Bier%2C_F._F.>
?:doi	10.1101/2020.11.24.20216663
?:doi	<https://research.tib.eu/covid-19/entity/10.1101/2020.11.24.20216663>
?:license	medrxiv
?:pdf_json_files	document_parses/pdf_json/3bc57f6398788d3a21ad2ba051e4caee28b1cad8.json
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/3bc57f6398788d3a21ad2ba051e4caee28b1cad8>
?:source	MedRxiv; WHO
?:title	Peptide microarray based detection of antibody responses against SARS-CoV-2 species-specific epitopes in spike and nucleocapsid proteins with potential for diagnostic test development
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-27

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