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?:abstract
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Objective: to analyse the frequency of cognitive impairment and other neurological comorbidities in deceased COVID-19 patients, during the outbreak of the pandemic in Madrid, Spain Methods: retrospective, single-center, hospital-based study We included adults that died after admission from March 1 to March 31, 2020, at Hospital Universitario 12 De Octubre Clinical and demographic data were extracted from electronic medical records Results: 477 cases: 58 with probable COVID-19, 281 confirmed COVID-19, and 138 who died of other causes Comparing the latter two groups, median age (81 4 years vs 78 1 years;p<0 01) and the proportion of males (62 3% vs 49 3%, p<0 01) were higher in the confirmed COVID-19 group The number of comorbidities was high and similar in both groups, and cognitive impairment was common (29 9%;21 1% dementia;8 9% mild cognitive impairment) in confirmed COVID-19 In this group group, subjects with cognitive impairment were older (median 85 8 years vs 79 0 years, p<0 0001), more lived in nursing homes and had slightly shorter times from symptom onset to death than those without cognitive impairment COVID-19 patients with cognitive impairment were rarely admitted to the ICU, and fewer received non-invasive mechanical ventilation (7 1% vs 25 4%, <0 0001) Palliative care was provided in more subjects with cognitive impairment (79 2% vs 66 3%, p=0 038) Conclusions: in our study, dead patients with confirmed COVID-19 were older and had more comorbidities than those reported in the Asian population Cognitive impairment is a frequent comorbidity in COVID-19 deceased patients The burden of COVID-19 in the dementia community will be high
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