l6qcaneo | Knowledge4COVID-19

Property	Value
?:abstract	Responsible for the ongoing coronavirus disease 19 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through binding of the viral spike protein (SARS-2-S) to the cell-surface receptor angiotensin-converting enzyme 2 (ACE2) Here we show that the high-density lipoprotein (HDL) scavenger receptor B type 1 (SR-B1) facilitates ACE2-dependent entry of SARS-CoV-2 We find that the S1 subunit of SARS-2-S binds to cholesterol and possibly to HDL components to enhance viral uptake in vitro SR-B1 expression facilitates SARS-CoV-2 entry into ACE2-expressing cells by augmenting virus attachment Blockade of the cholesterol-binding site on SARS-2-S1 with a monoclonal antibody, or treatment of cultured cells with pharmacological SR-B1 antagonists, inhibits HDL-enhanced SARS-CoV-2 infection We further show that SR-B1 is coexpressed with ACE2 in human pulmonary tissue and in several extrapulmonary tissues Our findings reveal that SR-B1 acts as a host factor that promotes SARS-CoV-2 entry and may help explain viral tropism, identify a possible molecular connection between COVID-19 and lipoprotein metabolism, and highlight SR-B1 as a potential therapeutic target to interfere with SARS-CoV-2 infection
is ?:annotates of	<https://research.tib.eu/covid-19/entity/l6qcaneo_hasAnnotation_C0019378> <https://research.tib.eu/covid-19/entity/l6qcaneo_hasAnnotation_C0599220> <https://research.tib.eu/covid-19/entity/l6qcaneo_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Wei%2C_C.%3B_Wan%2C_L.%3B_Yan%2C_Q.%3B_Wang%2C_X.%3B_Zhang%2C_J.%3B_Yang%2C_X.%3B_Zhang%2C_Y.%3B_Fan%2C_C.%3B_Li%2C_D.%3B_Deng%2C_Y.%3B_Sun%2C_J.%3B_Gong%2C_J.%3B_Wang%2C_Y.%3B_Li%2C_J.%3B_Yang%2C_H.%3B_Li%2C_H.%3B_Zhang%2C_Z.%3B_Wang%2C_R.%3B_Du%2C_P.%3B_Zong%2C_Y.%3B_Yin%2C_F.%3B_Zhang%2C_W.%3B_Wang%2C_N.%3B_Peng%2C_Y.%3B_Lin%2C_H.%3B_Feng%2C_J.%3B_Qin%2C_C.%3B_Chen%2C_W.%3B_Gao%2C_Q.%3B_Zhang%2C_R.%3B_Cao%2C_Y.%3B_Zhong%2C_H.>
?:journal	Nat_Metab
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/l6qcaneo_HAS_C0003250_DISRUPTS_C5203670> <https://research.tib.eu/covid-19/entity/l6qcaneo_HAS_C0599220_INTERACTS_WITH_C0008377> <https://research.tib.eu/covid-19/entity/l6qcaneo_HAS_C0960880_DISRUPTS_C5203670>
?:source	WHO
?:title	HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#947555
?:year	2020

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