PropertyValue
?:abstract
  • SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally We therefore compare the properties of the mutated S protein (S(G614)) with the original (S(D614)) We report here pseudoviruses carrying S(G614) enter ACE2-expressing cells more efficiently than those with S(D614) This increased entry correlates with less S1-domain shedding and higher S-protein incorporation into the virion Similar results are obtained with virus-like particles produced with SARS-CoV-2 M, N, E, and S proteins However, D614G does not alter S-protein binding to ACE2 or neutralization sensitivity of pseudoviruses Thus, D614G may increase infectivity by assembling more functional S protein into the virion
is ?:annotates of
?:creator
?:journal
  • Nat_Commun
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
?:type
?:who_covidence_id
  • #947533
?:year
  • 2020

Metadata

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<http://xmlns.com/foaf/0.1/topic> Anon_0
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