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MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the posttranscriptional level and play a crucial role in development and many diseases. The discovery of miRNAs has greatly expanded our understanding of the intricate scenario of genome-wide regulation. Over the last two decades, hundreds of virus-encoded miRNAs have been identified, most of which are from DNA viruses. Although the number of reported RNA virus-derived miRNAs is increasing, current knowledge of their roles in physiological and pathological processes has remained lacking. In this review, we discuss the biogenesis and biological functions of RNA virus- encoded miRNAs and their proposed roles in virus-host interactions and further underscore their potential value in the diagnosis and treatment of viral diseases.
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10.1186/s41544-020-00056-z
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document_parses/pdf_json/5ca542cbdf809ee57e3b3828919c6adb001e5626.json
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document_parses/pmc_json/PMC7548135.xml.json
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RNA virus-encoded microRNAs: biogenesis, functions and perspectives on application
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