PropertyValue
?:abstract
  • The linear polysaccharide λ-carrageenan is the only one among the carrageenans not forming secondary, tertiary, and quaternary structures in the presence of inorganic ions Chloroquine (CQ) is a well-established antimalaria drug also recently discussed in therapeutics against the COVID-19 pandemic The interaction of this polysaccharide-ionic drug pair was investigated by combining UV-vis spectrophotometry and atomic force microscopy (AFM) imaging A decrease of the UV peak assigned to free CQ and the occurrence of isosbestic points indicate the formation of complexes High-resolution AFM height images revealed an increasing height of the single polysaccharide chains in the random coil state upon addition of CQ, indicating the formation of a secondary structure, followed by higher hierarchical aggregates The disappearance of higher-ordered structures and the recovery of polysaccharide chains with primary structure were observed by introducing inorganic cations (Na+, K+, Ca2+), replacing the condensed CQ and paving the way to reversible ion-induced drug release Copyright © 2020 American Chemical Society
is ?:annotates of
?:creator
?:journal
  • ACS_Macro_Letters
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Formation of Higher Structural Levels in λ-Carrageenan Induced by the Antimalarial Drug Chloroquine
?:type
?:who_covidence_id
  • #824429
?:year
  • 2020

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