lorpo8uk | Knowledge4COVID-19

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?:abstract	Despite signs of infection, the involvement of the oral cavity in COVID-19 is poorly understood. To address this, single-cell RNA sequencing datasets were integrated from human minor salivary glands and gingiva to identify 11 epithelial, 7 mesenchymal, and 15 immune cell clusters. Analysis of SARS-CoV-2 viral entry factor expression showed enrichment in epithelia including the ducts and acini of the salivary glands and the suprabasal cells of the mucosae. COVID-19 autopsy tissues confirmed in vivo SARS CoV-2 infection in the salivary glands and mucosa. Saliva from SARS-CoV-2-infected individuals harbored epithelial cells exhibiting ACE2 expression and SARS-CoV-2 RNA. Matched nasopharyngeal and saliva samples found distinct viral shedding dynamics and viral burden in saliva correlated with COVID-19 symptoms including taste loss. Upon recovery, this cohort exhibited salivary antibodies against SARS-CoV-2 proteins. Collectively, the oral cavity represents a robust site for COVID-19 infection andimplicates saliva in viral transmission.
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?:creator	<https://research.tib.eu/covid-19/entity/Byrd%2C_K._M.%3B_Huang%2C_N.%3B_Perez%2C_P.%3B_Kato%2C_T.%3B_Mikami%2C_Y.%3B_Okuda%2C_K.%3B_Gilmore%2C_R._C.%3B_Conde%2C_C._D.%3B_Gasmi%2C_B.%3B_Stein%2C_S.%3B_Beach%2C_M.%3B_Pelayo%2C_E.%3B_Maldonado-Ortiz%2C_J.%3B_LaFont%2C_B.%3B_Padilla%2C_R.%3B_Murrah%2C_V.%3B_Maile%2C_R.%3B_Lovell%2C_W.%3B_Wallet%2C_S.%3B_Bowman%2C_N._M.%3B_Meinig%2C_S._L.%3B_Wolfgang%2C_M._C.%3B_Choudhury%2C_S._N.%3B_Novotny%2C_M.%3B_Aevermann%2C_B._D.%3B_Scheuermann%2C_R.%3B_Cannon%2C_G.%3B_Anderson%2C_C.%3B_Marchesan%2C_J.%3B_Bush%2C_M.%3B_Freire%2C_M.%3B_Kimple%2C_A.%3B_Herr%2C_D._L.%3B_Rabin%2C_J.%3B_Grazioli%2C_A.%3B_French%2C_B._N.%3B_Pranzatelli%2C_T._J.%3B_Chiorini%2C_J._A.%3B_Kleiner%2C_D._E.%3B_Pittaluga%2C_S.%3B_Hewitt%2C_S.%3B_Burbelo%2C_P._D.%3B_Chertow%2C_D.%3B_NIHCOVID-19%2C_A>
?:doi	10.1101/2020.10.26.20219089
?:doi	<https://research.tib.eu/covid-19/entity/10.1101/2020.10.26.20219089>
?:journal	medRxiv_:_the_preprint_server_for_health_sciences
?:license	medrxiv
?:pdf_json_files	document_parses/pdf_json/8e19b80f365a20591593f80798b1e84136400b5f.json
?:pmid	<https://research.tib.eu/covid-19/entity/33140061.0>
?:pmid	33140061.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/8e19b80f365a20591593f80798b1e84136400b5f>
?:source	MedRxiv; Medline; WHO
?:title	Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-10-27

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