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?:abstract
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BACKGROUND: To evaluate chest-computed-tomography (CT) scans in coronavirus-disease-2019 (COVID-19) patients for signs of organizing pneumonia (OP) and microinfarction as surrogate for microscopic thromboembolic events METHODS: Real-time polymerase-chain-reaction (RT-PCR)-confirmed COVID-19 patients undergoing chest-CT (non-enhanced, enhanced, pulmonary-angiography [CT-PA]) from March-April 2020 were retrospectively included (COVID-19-cohort) As control-groups served 175 patients from 2020 (cohort-2020) and 157 patients from 2019 (cohort-2019) undergoing CT-PA for pulmonary embolism (PE) during the respective time frame at our institution Two independent readers assessed for presence and location of PE in all three cohorts In COVID-19 patients additionally parenchymal changes typical of COVID-19 pneumonia, infarct pneumonia and OP were assessed Inter-reader agreement and prevalence of PE in different cohorts were calculated RESULTS: From 68 COVID-19 patients (42 female [61 8%], median age 59 years [range 32-89]) undergoing chest-CT 38 obtained CT-PA Inter-reader-agreement was good (k = 0 781) On CT-PA, 13 2% of COVID-19 patients presented with PE whereas in the control-groups prevalence of PE was 9 1% and 8 9%, respectively (p = 0 452) Up to 50% of COVID-19 patients showed changes typical for OP 21 1% of COVID-19 patients suspected with PE showed subpleural wedge-shaped consolidation resembling infarct pneumonia, while only 13 2% showed visible filling defects of the pulmonary artery branches on CT-PA CONCLUSION: Despite the reported hypercoagulability in critically ill patients with COVID-19, we did not encounter higher prevalence of PE in our patient cohort compared to the control cohorts However, patients with suspected PE showed a higher prevalence of lung changes, resembling patterns of infarct pneumonia or OP and CT-signs of pulmonary-artery hypertension
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