lwriue9h

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?:abstract	In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU) Hospitalized patients (n=34) with confirmed COVID-19 were recruited into a prospective cohort study Clinical data and blood samples were collected at inclusion and after 2-5 and 7-10 days RF was defined as PaO2/FiO2 ratio (P/F)<40 kPa Plasma cytokines were analyzed by a Human Cytokine 27-plex assay COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1 alpha levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0 79-0 80, p<0 05) During hospitalization the decline was most significant for IP-10 (p<0 001) Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19 IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2-5 and 7-10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79-0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.
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?:creator	<https://research.tib.eu/covid-19/entity/J%C3%B8ntvedt_J%C3%B8rgensen%2C_Marthe%3B_Holter%2C_Jan_Cato%3B_Christensen%2C_Erik_Egeland%3B_Schjalm%2C_Camilla%3B_Tonby%2C_Kristian%3B_Pischke%2C_S%C3%B8ren_Erik%3B_Jenum%2C_Synne%3B_Skeie%2C_Linda_G%3B_Nur%2C_Sarah%3B_Lind%2C_Andreas%3B_Opsand%2C_Hanne%3B_Enersen%2C_Tone_Burvald%3B_Gr%C3%B8ndahl%2C_Ragnhild%3B_Hermann%2C_Anne%3B_Dudman%2C_Susanne%3B_Muller%2C_Fredrik%3B_Ueland%2C_Thor%3B_Mollnes%2C_Tom_Eirik%3B_Aukrust%2C_P%C3%A5l%3B_Heggelund%2C_Lars%3B_Holten%2C_Aleksander_Rygh%3B_Dyrhol-Riise%2C_Anne_Ma> <https://research.tib.eu/covid-19/entity/Jorgensen%2C_M._J.%3B_Holter%2C_J._C.%3B_Christensen%2C_E._E.%3B_Schjalm%2C_C.%3B_Tonby%2C_K.%3B_Pischke%2C_S._E.%3B_Jenum%2C_S.%3B_Skeie%2C_L._G.%3B_Nur%2C_S.%3B_Lind%2C_A.%3B_Opsand%2C_H.%3B_Enersen%2C_T._B.%3B_Grondahl%2C_R.%3B_Hermann%2C_A.%3B_Dudman%2C_S.%3B_Muller%2C_F.%3B_Ueland%2C_T.%3B_Mollnes%2C_T._E.%3B_Aukrust%2C_P.%3B_Heggelund%2C_L.%3B_Holten%2C_A._R.%3B_Dyrhol-Riise%2C_A._M.>
?:journal	Sci_Rep Scientific_Reports
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C0021760_ASSOCIATED_WITH_C1145670> <https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C0079459_ASSOCIATED_WITH_C1145670> <https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C0087044_ASSOCIATED_WITH_C1145670> <https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C1145670_COEXISTS_WITH_C5203670> <https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C1449159_COEXISTS_WITH_C0021760> <https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C1449159_COEXISTS_WITH_C0245109> <https://research.tib.eu/covid-19/entity/lwriue9h_HAS_C1449159_COEXISTS_WITH_C1522712>
?:source	WHO
?:title	Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1059940 #971733
?:year	2020

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Value

?:abstract

In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU) Hospitalized patients (n=34) with confirmed COVID-19 were recruited into a prospective cohort study Clinical data and blood samples were collected at inclusion and after 2-5 and 7-10 days RF was defined as PaO2/FiO2 ratio (P/F)<40 kPa Plasma cytokines were analyzed by a Human Cytokine 27-plex assay COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1 alpha levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0 79-0 80, p<0 05) During hospitalization the decline was most significant for IP-10 (p<0 001) Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19 IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies
In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2-5 and 7-10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79-0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.

is ?:annotates of