PropertyValue
?:abstract
  • Background: MiR-146a, an effector mediator, targets Notch-1 and regulates the innate and adaptive immune systems response Recently, we reported that Notch-1 signaling plays a key role in macrophage polarization and response during infection We employed Mycobacterium avium paratuberculosis (MAP) infection in Crohn\'s disease (CD) as a model to demonstrate the role of Notch-1/IL-6 signaling on MCL-1 based apoptosis and intracellular MAP infection and persistence This study was designed to investigate the impact of polymorphisms in miR146a on the immune response and infection in our MAP-CD model
is ?:annotates of
?:creator
?:journal
  • Gut_Pathogens
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • MiR-146a rs2910164 G > C polymorphism modulates Notch-1/iL-6 signaling during infection: a possible risk factor for Crohn\'s disease
?:type
?:who_covidence_id
  • #914079
?:year
  • 2020

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