PropertyValue
?:abstract
  • COVID-19 has caused significant morbidity and mortality, and new cases are on the rise globally, yet malaria-endemic areas report statistically significant lower incidences. We identified potential shared targets for an immune response to SARS-CoV-2 by immune determinants shared identities with Plasmodium falciparum using IEDB\'s Immune browser tool 9.0. Probable cross-reactivity is suggested through HLA-A*02:01 and subsequent CD8+ T cell activation. The apparent immunodominant epitope conservation between SARS-COV-2 (N and Orf1ab) and P. falciparum thrombospondin-anonymous-related protein (TRAP) may underlie the low COVID-19 incidence in the malaria-endemic zone by providing immunity against virus infection to those previously infected with plasmodium. Additionally, the shared epitopes lie within antigens which aid in the establishment of the P. falciparum invasion to the erythrocytes may hypothesize an alternative route for SARS-CoV-2, though yet to be proven, via erythrocyte CD147 receptor.
is ?:annotates of
?:creator
?:journal
  • New_Microbes_New_Infect
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • SARS-COV2 and P. falciparum common immunodominant regions may explain low COVID-19 incidence in the malaria-endemic belt
?:type
?:who_covidence_id
  • #933389
?:year
  • 2020

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