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?:abstract
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Porcine epidemic diarrhea virus (PEDV) is a significant global, enteric coronavirus in pigs and was first reported in Colombia in 2014 However, the epidemiology, genetic, and antigenic characteristics of the virus have yet to be investigated In this study, we investigated the dissemination of PEDV by testing 536 samples by RT-PCR over a 33-month period The 35 8% of positive samples (n=192) was significantly different (p<0 01) between months over time, with a higher number of positives samples occurring at the beginning of the epidemic and during the second epidemic wave within the main pork producing region The complete PEDV genomes was generated for 21 strains, which shared a high nucleotide and amino acid sequence identity, except for the spike (S) gene Recombinant regions were identified within the Colombian strains and between Colombian and Asian PEDV strains Phylogenetic analysis of the 21 Colombian strains demonstrated the presence of 7 lineages that shared common ancestors with PEDV strains from the United States Moreover, the antigenic analysis demonstrated residue differences in the neutralizing epitopes in the spike and nucleocapsid proteins Our results illustrated the simultaneous introduction of the two PEDV genotypes (GIIa American pandemic and S-INDEL) into the Colombian swine industry during the 2014 PEDV epidemic and enhanced our understanding of the epidemiology and molecular diversity of PEDV in Colombia
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