mm8b6oja

Property	Value
?:abstract	Background SARS-CoV-2, the etiological agent causing COVID-19, has infected more than 27 million people with over 894000 deaths worldwide since its emergence in December 2019. Factors for severe diseases, such as diabetes, hypertension, and obesity have been identified however, the precise pathogenesis is poorly understood. To understand its pathophysiology and to develop effective therapeutic strategies, it is essential to define the prevailing immune cellular subsets. Methods We performed whole circulating immune cells scRNAseq from five critically ill COVID-19 patients, trajectory and gene ontology analysis. Results Immature myeloid populations, such as promyelocytes-myelocytes, metamyelocytes, band neutrophils, monocytoid precursors, and activated monocytes predominated. The trajectory with pseudotime analysis supported the finding of immature cell states. While the gene ontology showed myeloid cell activation in immune response, DNA and RNA processing, defense response to the virus, and response to type 1 interferon. Lymphoid lineage was scarce. Expression of genes such as C/EBPβ, IRF1and FOSL2 potentially suggests the induction of trained immunity. Conclusions Our results uncover transcriptomic profiles related to immature myeloid lineages and suggest the potential induction of trained immunity.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/mm8b6oja_hasAnnotation_C0017337> <https://research.tib.eu/covid-19/entity/mm8b6oja_hasAnnotation_C0037088> <https://research.tib.eu/covid-19/entity/mm8b6oja_hasAnnotation_C0042776> <https://research.tib.eu/covid-19/entity/mm8b6oja_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Vadillo%2C_Eduardo%3B_Taniguchi-Ponciano%2C_Keiko%3B_Lopez-Macias%2C_Constantino%3B_Carvente-Garcia%2C_Roberto%3B_Mayani%2C_Hector%3B_Ferat-Osorio%2C_Eduardo%3B_Flores-Padilla%2C_Guillermo%3B_Torres%2C_Javier%3B_Gonzalez-Bonilla%2C_Cesar_Raul%3B_Majluf%2C_Abraham%3B_Albarran-Sanchez%2C_Alejandra%3B_Galan%2C_Juan_Carlos%3B_Pe%C3%B1a-Mart%C3%ADnez%2C_Eduardo%3B_Silva-Rom%C3%A1n%2C_Gloria%3B_Vela-Pati%C3%B1o%2C_Sandra%3B_Ferreira-Hermosillo%2C_Aldo%3B_Ramirez-Renteria%2C_Claudia%3B_Espinoza-Sanchez%2C_Nancy_Adriana%3B_Pelayo-Camacho%2C_Rosana%3B_Bonifaz%2C_Laura%3B_Arriaga-Pizano%2C_Lourdes%3B_Mata-Lozano%2C_Carlos%3B_Andonegui-Elguera%2C_Sergio%3B_Wacher%2C_Niels%3B_Blanco-Favela%2C_Francisco%3B_De-Lira-Barraza%2C_Roberto%3B_Villanueva-Compean%2C_Humberto%3B_Esquivel-Pineda%2C_Alejandra%3B_Ram%C3%ADrez-Montes-de-Oca%2C_Rub%C3%A9n%3B_Anda-Garay%2C_Carlos%3B_Noyola-Garc%C3%ADa%2C_Maura%3B_Guizar-Garc%C3%ADa%2C_Luis%3B_Cerbulo-Vazquez%2C_Arturo%3B_Zamudio-Meza%2C_Horacio%3B_Marrero-Rodr%C3%ADguez%2C_Daniel%3B_Mercado%2C_Moises>
?:doi	10.1016/j.arcmed.2020.11.005
?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.arcmed.2020.11.005>
?:journal	Arch_Med_Res
?:license	els-covid
?:pdf_json_files	document_parses/pdf_json/6df0d37bedb08074ed4a458bd68aa4d9d140d581.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7670924>
?:pmid	<https://research.tib.eu/covid-19/entity/33248817.0>
?:pmid	33248817.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/6df0d37bedb08074ed4a458bd68aa4d9d140d581>
?:source	Elsevier; Medline; PMC
?:title	A Shift Towards an Immature Myeloid Profile in Peripheral Blood of Critically Ill COVID-19 Patients
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-17

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Value

?:abstract

Background SARS-CoV-2, the etiological agent causing COVID-19, has infected more than 27 million people with over 894000 deaths worldwide since its emergence in December 2019. Factors for severe diseases, such as diabetes, hypertension, and obesity have been identified however, the precise pathogenesis is poorly understood. To understand its pathophysiology and to develop effective therapeutic strategies, it is essential to define the prevailing immune cellular subsets. Methods We performed whole circulating immune cells scRNAseq from five critically ill COVID-19 patients, trajectory and gene ontology analysis. Results Immature myeloid populations, such as promyelocytes-myelocytes, metamyelocytes, band neutrophils, monocytoid precursors, and activated monocytes predominated. The trajectory with pseudotime analysis supported the finding of immature cell states. While the gene ontology showed myeloid cell activation in immune response, DNA and RNA processing, defense response to the virus, and response to type 1 interferon. Lymphoid lineage was scarce. Expression of genes such as C/EBPβ, IRF1and FOSL2 potentially suggests the induction of trained immunity. Conclusions Our results uncover transcriptomic profiles related to immature myeloid lineages and suggest the potential induction of trained immunity.

is ?:annotates of