PropertyValue
?:abstract
  • The rapid spread of SARS-CoV-2 has a significant impact on global health, travel and economy. Therefore, preventative and therapeutic measures are urgently needed. Here, we isolated monoclonal antibodies from three convalescent COVID-19 patients using a SARS-CoV-2 stabilized prefusion spike protein. These antibodies had low levels of somatic hypermutation and showed a strong enrichment in VH1-69, VH3-30-3 and VH1-24 gene usage. A subset of the antibodies were able to potently inhibit authentic SARS-CoV-2 infection as low as 0.007 μg/mL. Competition and electron microscopy studies illustrate that the SARS-CoV-2 spike protein contains multiple distinct antigenic sites, including several receptor-binding domain (RBD) epitopes as well as non-RBD epitopes. In addition to providing guidance for vaccine design, the antibodies described here are promising candidates for COVID-19 treatment and prevention.
?:creator
?:doi
?:doi
  • 10.1126/science.abc5902
?:journal
  • Science
?:license
  • cc-by
?:pmc_json_files
  • document_parses/pmc_json/PMC7299281.xml.json
?:pmcid
?:pmid
?:pmid
  • 32540902.0
?:publication_isRelatedTo_Disease
?:source
  • Medline; PMC
?:title
  • Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
?:type
?:year
  • 2020-06-15

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