PropertyValue
?:abstract
  • Aims: COVID-19 is a global pandemic that has affected around 186 countries in the world, related to clinical signs as fever, cough and pneumonia The disease is caused by SARS-CoV-2, in the pathophysiology of SARS-CoV-2 it presents the importance of different structural and functional proteins Some of these mechanisms are based on proteases such as 3CL-PRO and PL-PRO related to the specific cleavage of polypeptides to replication Materials and Methods: In order to search for alternatives to counteract the virus, computational screening tools have been used, employing molecular docking methodologies through natural ligands, drugs and analogues against SARS-CoV-2 proteases Subsequently, were tested by ligand-protein interaction employed AutoDock-Vina and PyRx 0 8
is ?:annotates of
?:creator
?:journal
  • Biomedical_&_Pharmacology_Journal
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Virtual screening of natural metabolites and antiviral drugs with potential inhibitory activity against 3 CL-PRO and PL-PRO
?:type
?:who_covidence_id
  • #937740
?:year
  • 2020

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