PropertyValue
?:abstract
  • There is emerging evidence for multifarious neurological manifestations of COVID-19, while little is known whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome indicating that neuronal injury is common and pronounced in critically ill patients. This article is protected by copyright. All rights reserved.
?:creator
?:doi
  • 10.1002/ana.26004
?:doi
?:journal
  • Annals_of_neurology
?:license
  • unk
?:pmid
?:pmid
  • 33377539.0
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • Serum neurofilament light chain levels in the intensive care unit: comparison between severely ill patients with and without COVID-19.
?:type
?:year
  • 2020-12-30

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