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?:abstract
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Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay on anal swabs was recently reported to be persistently positive even after throat testing was negative during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, data about the consistent performance of RT-PCR assay on throat and anal swabs remain limited in paediatric patients. Here, we retrospectively reviewed RT-PCR-testing results of 212 paediatric patients with suspected SARS-CoV-2 infection at Wuhan Children’s Hospital. The diagnostic potential of these two types of specimens showed significant difference (positive rate: 78.2% on throat swabs vs. 52.6% on anal swabs, McNemar Test P = 0.0091) and exhibited a weak positive consistency (Kappa value was 0.311, P < 0.0001) in paediatric patients. Furthermore, viral loads detected on both throat and anal swabs also showed no significant difference (P = 0.9511) and correlation (Pearson r = 0.0434, P = 0.8406), and exhibited an inconsistent kinetic change through the course of SARS-CoV-2 infection. Besides, viral loads in the throat and anal swabs were correlated with different types of immune states, immune-reactive phase, and the resolution phase/immunologic tolerance, respectively. These findings revealed that RT-PCR-testing on throat and anal swabs showed significant difference for monitoring SARS-CoV-2 infection and correlated with different immune state in paediatric patients.
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?:creator
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?:doi
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10.1080/22221751.2020.1771219
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?:doi
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?:journal
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Emerging_microbes_&_infections
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?:license
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?:pdf_json_files
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document_parses/pdf_json/b18950ea5fbbd22be0a25792c05d980312ce9049.json
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document_parses/pmc_json/PMC7450259.xml.json
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?:pmid
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?:pmid
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?:publication_isRelatedTo_Disease
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?:sha_id
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?:source
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?:title
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Viral loads in throat and anal swabs in children infected with SARS-CoV-2
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?:year
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