PropertyValue
?:abstract
  • The emergence of COVID-19 infection (caused by the SARS-CoV-2 virus) in Wuhan, China in the latter part of 2019 has, within a relatively short time, led to a global pandemic. Amidst the initial spread of SARS-CoV-2 across Asia, an epidemiologic trend emerged in relation to high altitude (HA) populations. Compared with the rest of Asia, SARS-CoV-2 exhibited attenuated rates of expansion with limited COVID-19 infection severity along the Tibetan plateau. These characteristics were soon evident in additional HA regions across Bolivia, central Ecuador, Nepal, Bhutan, and the Sichuan province of mainland China. This mini-review presents a discussion surrounding attributes of the HA environment, aspects of HA physiology, as well as, genetic variations among HA populations which may provide clues for this pattern of SARS-CoV-2 expansion and COVID-19 infection severity. Explanations are provided in the hypothetical, albeit relevant historical evidence is provided to create a foundation for future research.
?:creator
?:doi
?:doi
  • 10.1152/japplphysiol.00362.2020
?:journal
  • J_Appl_Physiol_(1985)
?:license
  • no-cc
?:pmc_json_files
  • document_parses/pmc_json/PMC7414234.xml.json
?:pmcid
?:pmid
?:pmid
  • 32702272.0
?:publication_isRelatedTo_Disease
?:source
  • Medline; PMC
?:title
  • Geographic components of SARS-CoV-2 expansion: a hypothesis
?:type
?:year
  • 2020-08-01

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