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?:abstract
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Background:It is unknown if COVID-19 will exhibit seasonal pattern as other diseases e.g., seasonal influenza. Similarly, some environmental factors (e.g., temperature, humidity) have been shown to be associated with transmission of SARS-CoV and MERS-CoV, but global data on their association with COVID-19 are scarce.Objective: To examine the association between climatic factors and COVID-19.Methods: We used multilevel mixed-effects (two-level random-intercepts) negative binomial regression models to examine the association between 7- and 14-day-lagged temperature, humidity (relative and absolute), wind speed and UV index and COVID-19 cases, adjusting for Gross Domestic Products, Global Health Security Index, cloud cover (%), precipitation (mm), sea-level air-pressure (mb), and daytime length. The effects estimates are reported as adjusted rate ratio (aRR) and their corresponding 95% confidence interval (CI).Results: Data from 206 countries (until April 20, 2020) with ≥100 reported cases each showed no association between COVID-19 cases and 7-day-lagged temperature, relative humidity, UV index, and wind speed, after adjusting for potential confounders, but a positive association with 14-day-lagged temperature and a negative association with 14-day-lagged wind speed. Compared to an absolute humidity <5g/m(3), an absolute humidity of 5-10g/m(3) was associated with a 23% (95% CI:6-42%) higher rate of COVID-19 cases, while absolute humidity >10g/m(3) did not have a significant effect. These findings were robust in the 14-day-lagged analysis.Conclusion: Our results of higher COVID-19 cases (through April 20) at absolute humidity of 5-10g/m(3) may be suggestive of a ‘sweet point’ for viral transmission, however only controlled laboratory experiments can decisively prove it.
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