n58o9osk

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?:abstract	Current evidence is limited to small studies describing the association between cardiac injury and outcomes in patients with coronavirus disease 2019 (COVID-19) To address this, we performed a comprehensive meta-analysis of studies in COVID-19 patients to evaluate the association between cardiac injury and all-cause mortality, intensive care unit (ICU) admission, mechanical ventilation, acute respiratory distress syndrome, acute kidney injury and coagulopathy Further, studies comparing cardiac biomarker levels in survivors versus nonsurvivors were included A total of 14 studies (3,175 patients) were utilized for the final analysis Cardiac injury in patients with COVID-19 was associated with higher risk of mortality (risk ratio [RR]:7 79;95% confidence interval [CI]: 4 69 to 13 01;I(2)=58%), ICU admission (RR: 4 06;95% CI: 1 50 to 10 97;I(2) = 61%), mechanical ventilation (RR: 5 53;95% CI: 3 09 to 9 91;I(2) = 0%), and developing coagulopathy (RR: 3 86;95% CI:2 81 to 5 32;I(2) = 0%) However, cardiac injury was not associated with increased risk of acute respiratory distress syndrome (RR:3 22;95% CI:0 72 to 14 47;I(2) = 73%) or acute kidney injury (RR: 11 52, 95% CI:0 03 to 4,159 80;I(2) = 0%) The levels of hs-cTnI (MD:34 54 pg/ml;95% CI: 24 67 to 44 40 pg/ml;I(2) = 88%), myoglobin (MD:186 81 ng/ml;95% CI: 121 52 to 252 10 ng/ml;I(2) = 88%), NT-pro BNP (MD:1183 55 pg/ml;95% CI: 520 19 to 1846 91 pg/ml: I(2) = 96%) and CK-MB (MD:2 49 ng/ml;95% CI: 1 86 to 3 12 ng/ml;I(2) = 90%) were significantly elevated in nonsurvivors compared with survivors with COVID-19 infection The results of this meta-analysis suggest that cardiac injury is associated with higher mortality, ICU admission, mechanical ventilation and coagulopathy in patients with COVID-19 Current evidence is limited to small studies describing the association between cardiac injury and outcomes in patients with coronavirus disease 2019 (COVID-19). To address this, we performed a comprehensive meta-analysis of studies in COVID-19 patients to evaluate the association between cardiac injury and all-cause mortality, intensive care unit (ICU) admission, mechanical ventilation, acute respiratory distress syndrome, acute kidney injury and coagulopathy. Further, studies comparing cardiac biomarker levels in survivors versus nonsurvivors were included. A total of 14 studies (3,175 patients) were utilized for the final analysis. Cardiac injury in patients with COVID-19 was associated with higher risk of mortality (risk ratio [RR]:7.79; 95% confidence interval [CI]: 4.69 to 13.01; I2=58%), ICU admission (RR: 4.06; 95% CI: 1.50 to 10.97; I2â¯=â¯61%), mechanical ventilation (RR: 5.53; 95% CI: 3.09 to 9.91; I2â¯=â¯0%), and developing coagulopathy (RR: 3.86; 95% CI:2.81 to 5.32; I2â¯=â¯0%). However, cardiac injury was not associated with increased risk of acute respiratory distress syndrome (RR:3.22; 95% CI:0.72 to 14.47; I2â¯=â¯73%) or acute kidney injury (RR: 11.52, 95% CI:0.03 to 4,159.80; I2â¯=â¯0%). The levels of hs-cTnI (MD:34.54 pg/ml;95% CI: 24.67 to 44.40 pg/ml; I2â¯=â¯88%), myoglobin (MD:186.81 ng/ml; 95% CI: 121.52 to 252.10 ng/ml; I2â¯=â¯88%), NT-pro BNP (MD:1183.55 pg/ml; 95% CI: 520.19 to 1846.91 pg/ml: I2â¯=â¯96%) and CK-MB (MD:2.49 ng/ml;95% CI: 1.86 to 3.12 ng/ml; I2â¯=â¯90%) were significantly elevated in nonsurvivors compared with survivors with COVID-19 infection. The results of this meta-analysis suggest that cardiac injury is associated with higher mortality, ICU admission, mechanical ventilation and coagulopathy in patients with COVID-19.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/n58o9osk_hasAnnotation_C0018805> <https://research.tib.eu/covid-19/entity/n58o9osk_hasAnnotation_C1424783>
?:creator	<https://research.tib.eu/covid-19/entity/Bansal%2C_A.%3B_Kumar%2C_A.%3B_Patel%2C_D.%3B_Puri%2C_R.%3B_Kalra%2C_A.%3B_Kapadia%2C_S._R.%3B_Reed%2C_G._W.> <https://research.tib.eu/covid-19/entity/Bansal%2C_Agam%3B_Kumar%2C_Ashish%3B_Patel%2C_Divyang%3B_Puri%2C_Rishi%3B_Kalra%2C_Ankur%3B_Kapadia%2C_Samir_R%3B_Reed%2C_Grant_W>
?:journal	Am._j._cardiol Am_J_Cardiol
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	WHO
?:title	Meta-analysis Comparing Outcomes in Patients With and Without Cardiac Injury and Coronavirus Disease 2019 (COVID 19)
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1059826 #932740
?:year	2020 2021

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?:abstract

Current evidence is limited to small studies describing the association between cardiac injury and outcomes in patients with coronavirus disease 2019 (COVID-19) To address this, we performed a comprehensive meta-analysis of studies in COVID-19 patients to evaluate the association between cardiac injury and all-cause mortality, intensive care unit (ICU) admission, mechanical ventilation, acute respiratory distress syndrome, acute kidney injury and coagulopathy Further, studies comparing cardiac biomarker levels in survivors versus nonsurvivors were included A total of 14 studies (3,175 patients) were utilized for the final analysis Cardiac injury in patients with COVID-19 was associated with higher risk of mortality (risk ratio [RR]:7 79;95% confidence interval [CI]: 4 69 to 13 01;I(2)=58%), ICU admission (RR: 4 06;95% CI: 1 50 to 10 97;I(2) = 61%), mechanical ventilation (RR: 5 53;95% CI: 3 09 to 9 91;I(2) = 0%), and developing coagulopathy (RR: 3 86;95% CI:2 81 to 5 32;I(2) = 0%) However, cardiac injury was not associated with increased risk of acute respiratory distress syndrome (RR:3 22;95% CI:0 72 to 14 47;I(2) = 73%) or acute kidney injury (RR: 11 52, 95% CI:0 03 to 4,159 80;I(2) = 0%) The levels of hs-cTnI (MD:34 54 pg/ml;95% CI: 24 67 to 44 40 pg/ml;I(2) = 88%), myoglobin (MD:186 81 ng/ml;95% CI: 121 52 to 252 10 ng/ml;I(2) = 88%), NT-pro BNP (MD:1183 55 pg/ml;95% CI: 520 19 to 1846 91 pg/ml: I(2) = 96%) and CK-MB (MD:2 49 ng/ml;95% CI: 1 86 to 3 12 ng/ml;I(2) = 90%) were significantly elevated in nonsurvivors compared with survivors with COVID-19 infection The results of this meta-analysis suggest that cardiac injury is associated with higher mortality, ICU admission, mechanical ventilation and coagulopathy in patients with COVID-19
Current evidence is limited to small studies describing the association between cardiac injury and outcomes in patients with coronavirus disease 2019 (COVID-19). To address this, we performed a comprehensive meta-analysis of studies in COVID-19 patients to evaluate the association between cardiac injury and all-cause mortality, intensive care unit (ICU) admission, mechanical ventilation, acute respiratory distress syndrome, acute kidney injury and coagulopathy. Further, studies comparing cardiac biomarker levels in survivors versus nonsurvivors were included. A total of 14 studies (3,175 patients) were utilized for the final analysis. Cardiac injury in patients with COVID-19 was associated with higher risk of mortality (risk ratio [RR]:7.79; 95% confidence interval [CI]: 4.69 to 13.01; I2=58%), ICU admission (RR: 4.06; 95% CI: 1.50 to 10.97; I2â¯=â¯61%), mechanical ventilation (RR: 5.53; 95% CI: 3.09 to 9.91; I2â¯=â¯0%), and developing coagulopathy (RR: 3.86; 95% CI:2.81 to 5.32; I2â¯=â¯0%). However, cardiac injury was not associated with increased risk of acute respiratory distress syndrome (RR:3.22; 95% CI:0.72 to 14.47; I2â¯=â¯73%) or acute kidney injury (RR: 11.52, 95% CI:0.03 to 4,159.80; I2â¯=â¯0%). The levels of hs-cTnI (MD:34.54 pg/ml;95% CI: 24.67 to 44.40 pg/ml; I2â¯=â¯88%), myoglobin (MD:186.81 ng/ml; 95% CI: 121.52 to 252.10 ng/ml; I2â¯=â¯88%), NT-pro BNP (MD:1183.55 pg/ml; 95% CI: 520.19 to 1846.91 pg/ml: I2â¯=â¯96%) and CK-MB (MD:2.49 ng/ml;95% CI: 1.86 to 3.12 ng/ml; I2â¯=â¯90%) were significantly elevated in nonsurvivors compared with survivors with COVID-19 infection. The results of this meta-analysis suggest that cardiac injury is associated with higher mortality, ICU admission, mechanical ventilation and coagulopathy in patients with COVID-19.

is ?:annotates of