PropertyValue
?:abstract
  • It is well established that cytokine storm is associated with more severe clinical course of COVID-19 Many clinical findings of COVID-19 and other severe viral infections (e g fever, muscle pain, respiratory distress, cough), are directly attributed to cytokine storm For example, IL-6 and IL-10 can be used as predictors for expedient diagnosis of patients with higher risk of deterioration Hyper-inflammatory status in patients with severe COVID-19 is to be mitigated to alleviate signs and symptoms in cytokine storm In case of deterioration of oxygenation and rapid progression of imaging (CT) findings, glucocorticoids can be used for a short time (3-5 days) for patients in whom overactivation of the body\'s inflammatory response is suspected On the other hand, interleukin-6 receptor antibodies tocilizumab, sarilumab, siltuximab can be used as immunomodulators, to suppress inflammation and to alleviate fever and other manifestations of immune response Their beneficial efficacy is especially remarkable during the cytokine storm period It should be kept in mind that the agents to be used in the management of any given patient should be tailored for each situation
?:creator
?:journal
  • Journal_of_Pharmaceutical_Research_International
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Cytokine Storm, Corticosteroids and Interleukin-6 Receptor Antibodies in Context of Antiinflammatory Treatment in COVID-19
?:type
?:who_covidence_id
  • #931366
?:year
  • 2020

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