PropertyValue
?:abstract
  • An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease We demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airways and decrease virus induced pathological sequelae when administered prophylactically or therapeutically in rhesus macaques Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs Our results provide evidence of the therapeutic potential of this antibody cocktail
is ?:annotates of
?:creator
?:journal
  • Science
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
?:type
?:who_covidence_id
  • #840630
?:year
  • 2020

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