nvphu1fm | Knowledge4COVID-19

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?:abstract	SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is the most divergent region of S, and provide epidemiological, clinical, and molecular characterization of a prevalent RBM variant, N439K. We demonstrate that N439K S protein has enhanced binding affinity to the hACE2 receptor, and that N439K virus has similar clinical outcomes and in vitro replication fitness as compared to wild- type. We observed that the N439K mutation resulted in immune escape from a panel of neutralizing monoclonal antibodies, including one in clinical trials, as well as from polyclonal sera from a sizeable fraction of persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/nvphu1fm_hasAnnotation_C0042776> <https://research.tib.eu/covid-19/entity/nvphu1fm_hasAnnotation_C1514562> <https://research.tib.eu/covid-19/entity/nvphu1fm_hasAnnotation_C1883559> <https://research.tib.eu/covid-19/entity/nvphu1fm_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Thomson%2C_Emma_C.%3B_Rosen%2C_Laura_E.%3B_Shepherd%2C_James_G.%3B_Spreafico%2C_Roberto%3B_da_Silva_Filipe%2C_Ana%3B_Wojcechowskyj%2C_Jason_A.%3B_Davis%2C_Chris%3B_Piccoli%2C_Luca%3B_Pascall%2C_David_J.%3B_Dillen%2C_Josh%3B_Lytras%2C_Spyros%3B_Czudnochowski%2C_Nadine%3B_Shah%2C_Rajiv%3B_Meury%2C_Marcel%3B_Jesudason%2C_Natasha%3B_De_Marco%2C_Anna%3B_Li%2C_Kathy%3B_Bassi%2C_Jessica%3B_O%E2%80%99Toole%2C_Aine%3B_Pinto%2C_Dora%3B_Colquhoun%2C_Rachel_M.%3B_Culap%2C_Katja%3B_Jackson%2C_Ben%3B_Zatta%2C_Fabrizia%3B_Rambaut%2C_Andrew%3B_Jaconi%2C_Stefano%3B_Sreenu%2C_Vattipally_B.%3B_Nix%2C_Jay%3B_Jarrett%2C_Ruth_F.%3B_Beltramello%2C_Martina%3B_Nomikou%2C_Kyriaki%3B_Pizzuto%2C_Matteo%3B_Tong%2C_Lily%3B_Cameroni%2C_Elisabetta%3B_Johnson%2C_Natasha%3B_Wickenhagen%2C_Arthur%3B_Ceschi%2C_Alessandro%3B_Mair%2C_Daniel%3B_Ferrari%2C_Paolo%3B_Smollett%2C_Katherine%3B_Sallusto%2C_Federica%3B_Carmichael%2C_Stephen%3B_Garzoni%2C_Christian%3B_Nichols%2C_Jenna%3B_Galli%2C_Massimo%3B_Hughes%2C_Joseph%3B_Riva%2C_Agostino%3B_Ho%2C_Antonia%3B_Semple%2C_Malcolm_G.%3B_Openshaw%2C_Peter_J.M.%3B_Baillie%2C_J._Kenneth%3B_Rihn%2C_Suzannah_J.%3B_Lycett%2C_Samantha_J.%3B_Virgin%2C_Herbert_W.%3B_Telenti%2C_Amalio%3B_Corti%2C_Davide%3B_Robertson%2C_David_L.%3B_Snell%2C_Gyorgy>
?:doi	10.1101/2020.11.04.355842
?:doi	<https://research.tib.eu/covid-19/entity/10.1101/2020.11.04.355842>
?:externalLink	<https://doi.org/10.1101/2020.11.04.355842>
?:journal	bioRxiv
?:license	biorxiv
?:pdf_json_files	document_parses/pdf_json/91dd66ca93ca31cf12517ea4287a36debd3b4c47.json
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/91dd66ca93ca31cf12517ea4287a36debd3b4c47>
?:source	BioRxiv; WHO
?:title	The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-05

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