PropertyValue
?:abstract
  • We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29–May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%–8.5% of persons did not seroconvert 3–6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.3201/eid2701.203074
?:journal
  • Emerg_Infect_Dis
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/0e3f505abf5b9946bb7f385e58d56e78d1666eb0.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7774532.xml.json
?:pmcid
?:pmid
?:pmid
  • 33256890.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
?:type
?:year
  • 2021-01-15

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