PropertyValue
?:abstract
  • Saporin, a type I ribosome-inactivating protein from soapwort plant, is a potent protein synthesis inhibitor Catalytically, saporin is a characteristic N-glycosidase, and it depurinates a specific adenine residue from a universally conserved loop of the major ribosomal RNA (rRNA) of eukaryotic cells It is well-known that saporin induces apoptosis through different pathways, including ribotoxic stress response, cell signal transduction, genomic DNA fragmentation and RNA abasic lyase (RAlyase) activity, and NAD(+) depletion by poly-(ADP)-ribose polymerase hyperactivation Saporin\'s high enzymatic activity, high stability, and resistance to conjugation procedures make it a well-suited tool for immunotherapy approaches In the present study, we focus on saporin-based targeted toxins that may be efficacious therapeutic agents for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection Our discussed points suggest that saporin may be a strategic molecule for therapeutic knockout treatments and a powerful candidate for novel drugs in the struggle against coronavirus 2019 (COVID-19)
is ?:annotates of
?:creator
?:journal
  • SLAS_Discov
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection
?:type
?:who_covidence_id
  • #913999
?:year
  • 2020

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