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Colchicine, in the form of Colchicum autumnale, has been used to treat joint swelling for centuries. The anti-inflammatory action of colchicine and the higher prevalence of calcium pyrophosphate crystal deposition (CPPD) in osteoarthritis (OA) joints have led to the use of colchicine as a potential treatment for OA, however, the quality of the evidence on this regards is still limited. The current protocol aims to conduct a systematic review and meta-analysis proving the efficacy and safety of colchicine for the treatment of adult patients with OA. For that purpose, Scopus, Web of Sciences, Medline and Cochrane Library will be inspected for the available trials testing the efficacy and safety of colchicine for the treatment of any type of OA (e.g., hand, knee or hip). Cochrane tool will be used to assess the risk of bias of included trials. A meta-analysis of dichotomous (e.g., adverse events) or continuous data (e.g., mean difference in pain scale) will be performed depending on the data reporting. Review Manager 5 (RevMan) and RStudio Version 1.2.1335 will be used to conduct the statistical analysis.
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10.1101/2020.11.20.20226589
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document_parses/pdf_json/1d3922ad20df6131cc4967b2fbe07b1263222613.json
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Efficacy and safety of colchicine for the treatment of osteoarthritis: protocol for a systematic review and meta-analysis of intervention trials
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