PropertyValue
?:abstract
  • We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2, and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU’s relevance to vertical transmission of SARS-CoV-2 is further warranted.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.placenta.2020.11.001
?:doi
?:journal
  • Placenta
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/ca819c2e9f0e9f2e47bfbd5fcc82303724370df8.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7649632.xml.json
?:pmcid
?:pmid
?:pmid
  • 33197855.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Connecting the Dots on Vertical Transmission SARS-CoV-2 Using Protein-Protein Interaction Network Analysis – Potential roles of placental ACE2 and ENDOU
?:type
?:year
  • 2020-11-09

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/oke224mq>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/oke224mq>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all