on3xkqi2

Property	Value
?:abstract	Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3 The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7 RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19 Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19 PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19 The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients) Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19 Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/on3xkqi2_hasAnnotation_C0021368> <https://research.tib.eu/covid-19/entity/on3xkqi2_hasAnnotation_C1419131>
?:creator	<https://research.tib.eu/covid-19/entity/Brunetta%2C_E.%3B_Folci%2C_M.%3B_Bottazzi%2C_B.%3B_De_Santis%2C_M.%3B_Gritti%2C_G.%3B_Protti%2C_A.%3B_Mapelli%2C_S._N.%3B_Bonovas%2C_S.%3B_Piovani%2C_D.%3B_Leone%2C_R.%3B_My%2C_I.%3B_Zanon%2C_V.%3B_Spata%2C_G.%3B_Bacci%2C_M.%3B_Supino%2C_D.%3B_Carnevale%2C_S.%3B_Sironi%2C_M.%3B_Davoudian%2C_S.%3B_Peano%2C_C.%3B_Landi%2C_F.%3B_Di_Marco%2C_F.%3B_Raimondi%2C_F.%3B_Gianatti%2C_A.%3B_Angelini%2C_C.%3B_Rambaldi%2C_A.%3B_Garlanda%2C_C.%3B_Ciccarelli%2C_M.%3B_Cecconi%2C_M.%3B_Mantovani%2C_A.> <https://research.tib.eu/covid-19/entity/Brunetta%2C_Enrico%3B_Folci%2C_Marco%3B_Bottazzi%2C_Barbara%3B_De_Santis%2C_Maria%3B_Gritti%2C_Giuseppe%3B_Protti%2C_Alessandro%3B_Mapelli%2C_Sarah_N%3B_Bonovas%2C_Stefanos%3B_Piovani%2C_Daniele%3B_Leone%2C_Roberto%3B_My%2C_Ilaria%3B_Zanon%2C_Veronica%3B_Spata%2C_Gianmarco%3B_Bacci%2C_Monica%3B_Supino%2C_Domenico%3B_Carnevale%2C_Silvia%3B_Sironi%2C_Marina%3B_Davoudian%2C_Sadaf%3B_Peano%2C_Clelia%3B_Landi%2C_Francesco%3B_Di_Marco%2C_Fabiano%3B_Raimondi%2C_Federico%3B_Gianatti%2C_Andrea%3B_Angelini%2C_Claudio%3B_Rambaldi%2C_Alessandro%3B_Garlanda%2C_Cecilia%3B_Ciccarelli%2C_Michele%3B_Cecconi%2C_Maurizio%3B_Mantovani%2C_Alberto>
?:journal	Nat._immunol Nature_Immunology
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/on3xkqi2_HAS_C0174234_PREDISPOSES_C0021368> <https://research.tib.eu/covid-19/entity/on3xkqi2_HAS_C1419131_ASSOCIATED_WITH_C5203670>
?:source	WHO
?:title	Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1065905 #933698
?:year	2020 2021

Property

Value

?:abstract

Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3 The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7 RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19 Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19 PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19 The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients) Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19
Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.

is ?:annotates of