PropertyValue
?:abstract
  • SARS-CoV-2 is a highly contagious virus and is causing a global pandemic. SARS-CoV-2 infection depends on the recognition of and binding to the cellular receptor human angiotensin-converting enzyme 2 (hACE2) through the receptor-binding domain (RBD) of the spike protein, and disruption of this process can effectively inhibit SARS-CoV-2 invasion. Plasma-activated water efficiently inactivates bacteria and bacteriophages by causing damage to biological macromolecules, but its effect on coronavirus has not been reported. In this study, pseudoviruses with the SARS-CoV-2 S protein were used as a model, and plasma-activated water (PAW) effectively inhibited pseudovirus infection through S protein inactivation. The RBD was used to study the molecular details, and the RBD binding activity was inactivated by plasma-activated water through the RBD modification. The short-lived reactive species in the PAW, such as ONOO(−), played crucial roles in this inactivation. Plasma-activated water after room-temperature storage of 30 days remained capable of significantly reducing the RBD binding with hACE2. Together, our findings provide evidence of a potent disinfection strategy to combat the epidemic caused by SARS-CoV-2.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.cej.2020.127742
?:doi
?:journal
  • Chem_Eng_J
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/ce9e655b0cd7edab3dcb9bde58e767f39fcb7bcf.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7677677.xml.json
?:pmcid
?:pmid
?:pmid
  • 33235538.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Plasma-activated water: an alternative disinfectant for S protein inactivation to prevent SARS-CoV-2 infection
?:type
?:year
  • 2020-11-20

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