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Objective The defective interplay between coagulation and inflammation may be the leading cause of intravascular coagulation and organ dysfunction in COVID-19 patients. Abnormal coagulation profiles were reported to be associated with poor outcomes. In this study, we assessed the prognostic values of antithrombin (AT) activity levels and the impact of fresh frozen plasma (FFP) treatment on outcome. Materials and Methods Conventional coagulation parameters as well as AT activity levels and outcomes of 104 consecutive critically ill acute respiratory distress syndrome (ARDS) patients with laboratory confirmed COVID-19 disease were retrospectively analyzed. Patients with AT activity below 75% were treated with FFP. Maximum AT activity levels achieved in those patients were recorded. Results Significantly low levels of admission AT activity were recorded in non-surviving patients (73%). The cutoff level for admission AT activity was 79% and 58% for the lowest AT for survival. The outcome in those patients who had AT activity levels above 75% after FFP treatment was better than the nonresponding group. As well as AT, admission values of d-dimer, C-reactive protein, and procalcitonin were coagulation and inflammatory parameters among the mortality risk factors. Conclusion AT activity could be used as a prognostic marker for survival and organ failure in COVID-19 associated ARDS patients. Antithrombin supplementation therapy with FFP in patients with COVID-19 induced hypercoagulopathy may improve thrombosis prophylaxis and thus have an impact on survival.
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?:doi
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10.4274/tjh.galenos.2021.2020.0695
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Turkish_journal_of_haematology_:_official_journal_of_Turkish_Society_of_Haematology
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Prognostic Value of Antithrombin Levels in COVID-19 Patients and Impact of Fresh Frozen Plasma Treatment: A Retrospective Study.
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