PropertyValue
?:abstract
  • Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) continues to spread worldwide, with 25 million confirmed cases and 800 thousand deaths. Effective treatments to target SARS-CoV-2 are urgently needed. In the present study, we have identified a class of cyclic sulfonamide derivatives as novel SARS-CoV-2 inhibitors. Compound 13c of the synthesized compounds exhibited robust inhibitory activity (IC50 = 0.88 µM) against SARS-CoV-2 without cytotoxicity (CC50 > 25 µM), with a selectivity index (SI) of 30.7. In addition, compound 13c exhibited high oral bioavailability (77%) and metabolic stability with good safety profiles in hERG and cytotoxicity studies. The present study identified that cyclic sulfonamide derivatives are a promising new template for the development of anti-SARS-CoV-2 agents.
is ?:annotates of
?:creator
?:journal
  • Bioorg_Med_Chem_Lett
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2
?:type
?:who_covidence_id
  • #907172
?:year
  • 2021

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