PropertyValue
?:abstract
  • Although fever is one of the main presenting symptoms of COVID-19 infection, little public attention has been given to fever as an evolved defense. Fever, the regulated increase in body temperature, is part of the evolved systemic reaction to infection known as the acute phase response. The heat of fever augments the performance of immune cells, induces stress on pathogens and infected cells directly, and combines with other stressors to provide a nonspecific immune defense. Observational trials in humans suggests a survival benefit from fever, and randomized trials published before COVID-19 do not support fever reduction in patients with infection. Like public health measures that seem burdensome and excessive, fevers involve costly tradeoffs but they can prevent infection from getting out of control. For infections with novel SARS-CoV-2, the precautionary principle applies: unless evidence suggests otherwise, we advise that fever should be allowed to run its course.
is ?:annotates of
?:creator
?:doi
  • 10.1093/emph/eoaa044
?:doi
?:externalLink
?:journal
  • Evol_Med_Public_Health
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/b2274222040bbf9918c5a6dd39f61f464d7872a2.json
?:pmcid
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • Let fever do its job: the meaning of fever in the pandemic era
?:type
?:year
  • 2020-11-23

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