ozitpm73 | Knowledge4COVID-19

Property	Value
?:abstract	SARS-CoV-2 is a new pandemic virus for which Remdesivir is the only antiviral available. We report the occurrence of a mutation in the RdRP (D484Y) following failure of remdesivir in a 76-year-old woman with a post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. Cure was reached after supplementation with convalescent plasma.
?:creator	<https://research.tib.eu/covid-19/entity/Martinot%2C_Martin%3B_Jary%2C_Aude%3B_Fafi-Kremer%2C_Samira%3B_Leducq%2C_Valentin%3B_Delagreverie%2C_Heloise%3B_Garnier%2C_Marc%3B_Pacanowski%2C_J%C3%A9r%C3%B4me%3B_M%C3%A9kinian%2C_Ars%C3%A8ne%3B_Pirenne%2C_France%3B_Tiberghien%2C_Pierre%3B_Calvez%2C_Vincent%3B_Humbrecht%2C_Catherine%3B_Marcelin%2C_Anne-Genevi%C3%A8ve%3B_Lacombe%2C_Karine>
?:doi	10.1093/cid/ciaa1474
?:doi	<https://research.tib.eu/covid-19/entity/10.1093/cid/ciaa1474>
?:journal	Clin_Infect_Dis
?:license	no-cc
?:pdf_json_files	document_parses/pdf_json/c16174fa6387303fb049ccc642a171fc676eb2c0.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7543308>
?:pmid	<https://research.tib.eu/covid-19/entity/32986807.0>
?:pmid	32986807.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/c16174fa6387303fb049ccc642a171fc676eb2c0>
?:source	Medline; PMC
?:title	Remdesivir failure with SARS-CoV-2 RNA-dependent RNA-polymerase mutation in a B-cell immunodeficient patient with protracted Covid-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-09-28

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