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Breast cancer is the leading cause of cancer death among females It occurs due to the uncontrolled proliferation of breast epithelial cells Plant-derived drugs are more efficacious than synthetic drugs since it lacks side effects Andrographolide is an active principle of the herb Andrographis paniculata (Burm f ) Nees It is a potent therapeutic drug against breast carcinoma It induces breast cancer cell‐cycle arrest at the G0/G1 phase via the induction of cell‐cycle inhibitory protein p27 and decreases the expression of cyclin‐dependent kinase 4 (CDK4) It also activates the intrinsic apoptotic pathway, via the induction of Bax and Bak It enhances caspase production and p53 gene expression Andrographolide inhibits angiogenesis and metastasis of breast carcinoma Andrographolide nanoparticle production and synergetic therapies of andrographolide, along with other chemotherapeutic drugs, is a breakthrough in breast cancer treatment
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International_Journal_of_Pharmacognosy_and_Phytochemical_Research
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Andrographolide a potential therapeutic drug against breast cancer: A review
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