PropertyValue
?:abstract
  • The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related comorbidities are strictly related with worse clinical outcomes of COVID-19 disease. Recently, there is a growing interest in the clinical use of ketogenic diets (KDs), particularly in the context of severe obesity with related metabolic complications. KDs have been proven effective for a rapid reduction of fat mass, preserving lean mass and providing an adequate nutritional status. In particular, the physiological increase in plasma levels of ketone bodies exerts important anti-inflammatory and immunomodulating effects, which may reveal as precious tools to prevent infection and potential adverse outcomes of COVID-19 disease. We discuss here the importance of KDs for a rapid reduction of several critical risk factors for COVID-19, such as obesity, type 2 diabetes and hypertension, based on the known effects of ketone bodies on inflammation, immunity, metabolic profile and cardiovascular function. We do believe that a rapid reduction of all modifiable risk factors, especially obesity with its metabolic complications, should be a pillar of public health policies and interventions, in view of future waves of SARS-CoV-2 infection.
is ?:annotates of
?:creator
?:doi
  • 10.1186/s12967-020-02600-9
?:doi
?:journal
  • J_Transl_Med
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/9180737b9284b9b8cefde0f77d4e5aac1bebac37.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7677746.xml.json
?:pmcid
?:pmid
?:pmid
  • 33218357.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogenic diet?
?:type
?:year
  • 2020-11-20

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