PropertyValue
?:abstract
  • The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) represents a major pandemic event nowadays. Since its origin in China in December 2019, there is compelling evidence that novel SARS-CoV-2 is a highly transmissible virus, and it is associated to a broad clinical spectrum going from subclinical presentation to severe respiratory distress and multiorgan failure. Like other coronaviruses, SARS-CoV-2 recognizes human angiotensin-converting enzyme 2 as a cellular receptor that allows it to infect different host cells and likely disrupts renin-angiotensin-aldosterone system homeostasis. Particularly, a considerable incidence of many renal abnormalities associated to COVID-19 has been reported, including proteinuria, hematuria, and acute kidney injury. Moreover, it has been recently demonstrated that SARS-CoV-2 can infect podocytes and tubular epithelial cells, which could contribute to the development of the aforementioned renal abnormalities. In this review, we discuss the biological aspects of SARS-CoV-2 infection, how understanding current knowledge about SARS-CoV-2 infection may partly explain the involvement of the kidneys in the pathophysiology of COVID-19, and what questions have arisen and remain to be explored.
?:creator
?:doi
  • 10.1152/ajprenal.00160.2020
?:doi
?:journal
  • Am_J_Physiol_Renal_Physiol
?:license
  • no-cc
?:pmc_json_files
  • document_parses/pmc_json/PMC7303722.xml.json
?:pmcid
?:pmid
?:pmid
  • 32412303.0
?:publication_isRelatedTo_Disease
?:source
  • Medline; PMC
?:title
  • Is the kidney a target of SARS-CoV-2?
?:type
?:year
  • 2020-06-01

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