poasj7lu

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?:abstract	Viral infections are known to lead to serious respiratory complications in cystic fibrosis (CF) patients. Hypothesizing that CF patients were a population at high risk for severe respiratory complications from SARS-CoV-2 infection, we conducted a national study to describe the clinical expression of COVID-19 in French CF patients. This prospective observational study involves all 47 French CF centers caring for approximately 7500 CF patients. Between 1 March and 30 June 2020, 31 patients were diagnosed with COVID-19: 19 had positive SARS-CoV-2 RT-PCR in nasopharyngeal swabs; 1 had negative RT-PCR but typical COVID-19 signs on a CT scan; and 11 had positive SARS-CoV-2 serology. Fifteen were males, median (range) age was 31 (9–60) years, and 12 patients were living with a lung transplant. The majority of the patients had CF-related diabetes (n = 19, 61.3%), and a mild lung disease (n = 19, 65%, with percent-predicted forced expiratory volume in 1 s (ppFEV(1)) > 70). Three (10%) patients remained asymptomatic. For the 28 (90%) patients who displayed symptoms, most common symptoms at admission were fever (n = 22, 78.6%), fatigue (n = 14, 50%), and increased cough (n = 14, 50%). Nineteen were hospitalized (including 11 out of the 12 post-lung transplant patients), seven required oxygen therapy, and four (3 post-lung transplant patients) were admitted to an Intensive Care Unit (ICU). Ten developed complications (including acute respiratory distress syndrome in two post-lung transplant patients), but all recovered and were discharged home without noticeable short-term sequelae. Overall, French CF patients were rarely diagnosed with COVID-19. Further research should establish whether they were not infected or remained asymptomatic upon infection. In diagnosed cases, the short-term evolution was favorable with rare acute respiratory distress syndrome and no death. Post-lung transplant patients had more severe outcomes and should be monitored more closely.
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?:creator	<https://research.tib.eu/covid-19/entity/Corvol%2C_Harriet%3B_de_Miranda%2C_Sandra%3B_Lemonnier%2C_Lydie%3B_Kemgang%2C_Astrid%3B_Reynaud_Gaubert%2C_Martine%3B_Chiron%2C_Raphael%3B_Dalphin%2C_Marie-Laure%3B_Durieu%2C_Isabelle%3B_Dubus%2C_Jean-Christophe%3B_Houdouin%2C_V%C3%A9ronique%3B_Prevotat%2C_Anne%3B_Ramel%2C_Sophie%3B_Revillion%2C_Marine%3B_Weiss%2C_Laurence%3B_Guillot%2C_Loic%3B_Boelle%2C_Pierre-Yves%3B_Burgel%2C_Pierre-R%C3%A9gis>
?:doi	<https://research.tib.eu/covid-19/entity/10.3390/jcm9113624>
?:doi	10.3390/jcm9113624
?:journal	J_Clin_Med
?:license	cc-by
?:pdf_json_files	document_parses/pdf_json/fa3704b43aaf84f0c7f673f21cabedbec08e9977.json
?:pmc_json_files	document_parses/pmc_json/PMC7697588.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7697588>
?:pmid	<https://research.tib.eu/covid-19/entity/33182847.0>
?:pmid	33182847.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/poasj7lu_HAS_C0161818_MANIFESTATION_OF_C5203670>
?:sha_id	<https://research.tib.eu/covid-19/entity/fa3704b43aaf84f0c7f673f21cabedbec08e9977>
?:source	Medline; PMC
?:title	First Wave of COVID-19 in French Patients with Cystic Fibrosis
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-10

Property

Value

?:abstract

Viral infections are known to lead to serious respiratory complications in cystic fibrosis (CF) patients. Hypothesizing that CF patients were a population at high risk for severe respiratory complications from SARS-CoV-2 infection, we conducted a national study to describe the clinical expression of COVID-19 in French CF patients. This prospective observational study involves all 47 French CF centers caring for approximately 7500 CF patients. Between 1 March and 30 June 2020, 31 patients were diagnosed with COVID-19: 19 had positive SARS-CoV-2 RT-PCR in nasopharyngeal swabs; 1 had negative RT-PCR but typical COVID-19 signs on a CT scan; and 11 had positive SARS-CoV-2 serology. Fifteen were males, median (range) age was 31 (9–60) years, and 12 patients were living with a lung transplant. The majority of the patients had CF-related diabetes (n = 19, 61.3%), and a mild lung disease (n = 19, 65%, with percent-predicted forced expiratory volume in 1 s (ppFEV(1)) > 70). Three (10%) patients remained asymptomatic. For the 28 (90%) patients who displayed symptoms, most common symptoms at admission were fever (n = 22, 78.6%), fatigue (n = 14, 50%), and increased cough (n = 14, 50%). Nineteen were hospitalized (including 11 out of the 12 post-lung transplant patients), seven required oxygen therapy, and four (3 post-lung transplant patients) were admitted to an Intensive Care Unit (ICU). Ten developed complications (including acute respiratory distress syndrome in two post-lung transplant patients), but all recovered and were discharged home without noticeable short-term sequelae. Overall, French CF patients were rarely diagnosed with COVID-19. Further research should establish whether they were not infected or remained asymptomatic upon infection. In diagnosed cases, the short-term evolution was favorable with rare acute respiratory distress syndrome and no death. Post-lung transplant patients had more severe outcomes and should be monitored more closely.

is ?:annotates of