PropertyValue
?:abstract
  • Background Transmission dynamics of SARS-CoV-2 varied by the settings of virus exposure. Understanding the inter-relationship between exposure setting and transmission networks would provide a basis for informing public health control strategies. Methods Surveillance and clinical data from the first wave of COVID-19 outbreaks in Hong Kong were accessed. Twelve exposure setting types were differentiated โ€“ household, neighbourhood, eateries, entertainment, parties, shopping, personalised service, workplace, education, worship, healthcare, transport. Clustering was investigated followed by reconstructing the transmission cascades of clustered cases using social networking approach. Linked and unlinked cases were compared in statistical analyses. Findings Between 23 January and 19 June 2020, 1128 cases were reported. Among 324 cases related to local transmission, 123 clusters comprising two or more epidemiologically linked cases were identified. Linked cases had lower Ct value (p < 0ยท001) than unlinked cases. Households accounted for 63% of all clusters with half as primary setting, while entertainment accounted for the highest number of primary setting transmission cases. There were altogether 19 cascades involving >1 exposure setting, with a median reproduction number of 3(IQR: 2โ€“4), versus 1(IQR:1โ€“2) for cascades involving a single setting (n = 36 cascades). The longest cascade featured a bar (entertainment) as primary setting, with propagation through 30 non-primary exposure settings from seven setting types, reflecting, propensity for widespread dispersion and difficulty in containment. Interpretation There was marked heterogeneity in the characteristics of SARS-CoV-2 transmission cascades which differed by exposure setting. Network epidemiological analyses of transmission cascades can be applied as a risk assessment tool in decision-making for calibrating social distancing measures. Funding Health and Medical Research Fund
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.lanwpc.2020.100052
?:doi
?:journal
  • The_Lancet_Regional_Health_-_Western_Pacific
?:license
  • els-covid
?:pdf_json_files
  • document_parses/pdf_json/7089474e9b573fafed7241f19ad4e84dc2bea9cc.json
?:pmcid
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Elsevier; PMC
?:title
  • Settings of virus exposure and their implications in the propagation of transmission networks in a COVID-19 outbreak
?:type
?:year
  • 2020-11-30

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