PropertyValue
?:abstract
  • BACKGROUND: Proteomic characterization of cancers is essential for a comprehensive understanding of key molecular aberrations. However, proteomic profiling of a large cohort of cancer tissues is often limited by the conventional approaches. METHODS: We present a proteomic landscape of 16 major types of human cancer, based on the analysis of 126 treatment-naïve primary tumor tissues, 94 tumor-matched normal adjacent tissues, and 12 normal tissues, using mass spectrometry-based data-independent acquisition approach. RESULTS: In our study, a total of 8527 proteins were mapped to brain, head and neck, breast, lung (both small cell and non-small cell lung cancers), esophagus, stomach, pancreas, liver, colon, kidney, bladder, prostate, uterus and ovary cancers, including 2458 tissue-enriched proteins. Our DIA-based proteomic approach has characterized major human cancers and identified universally expressed proteins as well as tissue-type-specific and cancer-type-specific proteins. In addition, 1139 therapeutic targetable proteins and 21 cancer/testis (CT) antigens were observed. CONCLUSIONS: Our discoveries not only advance our understanding of human cancers, but also have implications for the design of future large-scale cancer proteomic studies to assist the development of diagnostic and/or therapeutic targets in multiple cancers.
is ?:annotates of
?:creator
?:doi
  • 10.1186/s13045-020-01013-x
?:doi
?:externalLink
?:journal
  • J_Hematol_Oncol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/0ea0e6ea06a1c4bc81a285098a10ced714b31f44.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7720039.xml.json
?:pmcid
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets
?:type
?:year
  • 2020-12-07

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