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SESSION TITLE: Chest Infections Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: We conduct a retrospective study of hospital admissions associated with coronavirus (CoV) infection in the years 2016 and 2017 in the United States (U S ) Since there was no reported Severe Acute Respiratory Syndrome (SARS) or Middle East respiratory syndrome coronavirus (MERS)-CoV infection in the U S over the period, all CoV infections in this study were presumably caused by serotype 229E, NL63, HKU1, or OC43 METHODS: We used the National Inpatient Sample (NIS) to analyze approximately 70 million inpatient admissions in the U S in 2016 and 2017 Admissions with discharge diagnosis included CoV infection and other non-bacterial respiratory pathogen infections (NBRPI) were identified using International Classification of Diseases, Tenth Revision, Clinical Modification/Procedure Coding System (ICD-10-CM) Multivariate logistic regression was used to model binary dependent variables Covariates showed statistically significant association with dependent variables on univariate logistic regression were selected as confounders in multivariate logistic regression All p-values were two-sided, with 0 05 as the threshold for statistical significance RESULTS: There were 4,795 patients admitted to acute-care hospitals with at least one discharge diagnosis of CoV associated infections in the U S from 2016 to 2017, which constitutes 0 57% of all NBRPI, or 1 12% of non-influenza NBRPI The age distribution of CoV infection was bimodal Compared to other NBRPI, CoV related admissions occurred more often in pediatric patients and less common in elderly patients The peak month for CoV was January, while for other NBRPI was February Statistical differences between CoV infection and other NBRPI existed in sex, comorbidities, hospital characteristics, and geographic locations, but not in socioeconomic characteristics Bacterial pneumonia (aOR 0 42, P < 0 001) and sepsis (aOR 0 62, P = 0 015) were less common in CoV infections compared to other NBRPI For the rate of in-hospital mortality, mechanical ventilation with intubation, and acute kidney injury, there was no statistically significant difference between CoV infection and other NBRPI The mean length of stay and cost of hospitalization for CoV infection and other NBRPI were similar (P = 0 815 and 0 196, respectively) The total cost of all CoV related admissions in 2016 and 2017 was approximately 71 2 million U S dollars CONCLUSIONS: Our study summarized epidemiology, complications, mortality, and resource utilization of non-SARS/MERS CoV related hospitalization in the U S in 2016 and 2017 CLINICAL IMPLICATIONS: Our study adds to the knowledge of epidemiology, complications, mortality, and resource utilization of non-SARS/MERS CoV infection DISCLOSURES: No relevant relationships by Dan Kazmierski, source=Web Response No relevant relationships by Si Li, source=Web Response No relevant relationships by Pius Ochieng, source=Web Response No relevant relationships by Palakkumar Patel, source=Web Response No relevant relationships by NISHANT SHARMA, source=Web Response No relevant relationships by Yichen Wang, source=Web Response
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