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?:abstract
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BACKGROUND: To date, the effects of COVID-19 pneumonia on health-related quality of life (HRQoL) and dyspnoea are unknown METHODS: In a real-life observational study, 20 patients with COVID-19-related pneumonia received usual care plus erdosteine (300 mg twice daily) for 15 days after hospital discharge following local standard operating procedures At discharge (T0) and on Day 15 (T1), participants completed the St George\'s Respiratory Questionnaire (SGRQ), the modified Medical Research Council (mMRC) scale of dyspnoea during daily activity, the BORG scale for dyspnoea during exertion, and Visual Analogue Scale (VAS) for dyspnoea at rest Paired t-tests compared scores at T0 and T1 RESULTS: The mean (SD) SGRQ total score decreased from 25 5 (15 5) at T0 to 16 9 (13 2) at T1 (p<0 01);65% of patients achieved a clinically important change of ≥4 points SGRQ domain scores (symptoms, activity, and impact) were also significantly reduced (all p<0 01) The mean (SD) VAS score decreased from 1 6 (1 7) to 1 4 (2 5);p<0 01 The mean mMRC score decreased significantly (p=0 031) and 30% of patients achieved a clinically important change of ≥1 point The mean (SD) Borg score increased from 12 8 (4 2) to 14 3 (2 4);p<0 01 CONCLUSION: The present proof of concept study is the first to report HRQoL in patients with COVID-19 During 15 days after hospital discharge, patients reported significant improvements in HRQoL and dyspnoea at rest and during daily activities
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