PropertyValue
?:abstract
  • Purpose: In this work, we set out to provide an experimental setup, using Cs-131, with associated dosimetry for studying relative biological effectiveness (RBE) of Auger emitters.Material & Methods: Cs-131 decays by 100% electron capture producing K- (9%) and L- (80%) Auger electrons with mean energies of 26 keV and 3.5 keV, respectively, plus ≈ 9.4 very low energy electrons (<0.5 keV) per decay. Cs-131 accumulates in the cells through the Na+/K+-ATPase. By this uptake mechanism and the alkali chemistry of Cs+, we argue for its intracellular homogeneous distribution. Cs-131 was added to the cell culture medium of HeLa and V79 Cells. The bio-kinetics of Cs-131 (uptake, release, intracellular distribution) was examined by measuring its intracellular activity concentration over time. Taking advantage of the 100% confluent cellular monolayer, we developed a new and robust dosimetry that is entrusted to a quantity called SC-value.Results: The SC-values evaluated in the cell nucleus are almost independent of the nuclear size and geometry. We obtained dose-rate controlled RBE-values for intracellular Cs-131 decay. Using the γH2AX assay, the RBE was 1 for HeLa cells. Using the clonogenic cell survival, it was 3.9 for HeLa cells and 3.2 for V79 cells.Conclusion: This experimental setup and dosimetry provides reliable RBE-values for Auger emitters in various cell lines.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1080/09553002.2020.1787541
?:journal
  • International_journal_of_radiation_biology
?:license
  • unk
?:pmid
?:pmid
  • 32600084
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • Cs-131 as an Experimental Tool for the Investigation and Quantification of the Radiotoxicity of Intracellular Auger Decays in vitro.
?:type
?:year
  • 2020-06-30

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