?:abstract
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The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have a ripple effect that puts men at a risk of infertility This article reviews the possible link between SARS-CoV-2 infection and male reproduction following speculations that the single- stranded RNA viruses could directly invade the testes SARS-CoV-2 enters the human lung cells via angiotensin converting enzyme 2 (ACE2) ACEs, its products, angiotensin-(1-7), and its receptor, MAS receptor, are expressed in the testes Although the binding of SAR-CoV-2 to ACE2 could lead to excess angiotensin II with possible enhanced inflammation, angiotensin II could also promote sperm motility In addition, the pathophysiology of SAR-CoV-2, especially in relation to male fertility, is yet to be fully understood;the suppression of androgen observed in COVID-19 infected men calls for the need for andrological assessment in infected male
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