PropertyValue
?:abstract
  • The heterogeneous disease course of COVID-19 is unpredictable, ranging from mild self-limiting symptoms to cytokine storms, acute respiratory distress syndrome (ARDS), multi-organ failure and death Identification of high-risk cases will enable appropriate intervention and escalation This study investigates the routine laboratory tests and cytokines implicated in COVID-19 for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p ≤ 0 001) IL-6 levels of ≥3 27 pg/ml provide a sensitivity of 0 87 and specificity of 0 64 for a requirement of ventilation, and a CRP of ≥37 mg/l of 0 91 and 0 66 Reliable stratification of high-risk cases has significant implications on patient triage, resource management and potentially the initiation of novel therapies in severe patients
is ?:annotates of
?:creator
?:journal
  • Clin_Immunol
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Laboratory biomarkers associated with COVID-19 severity and management
?:type
?:who_covidence_id
  • #912100
?:year
  • 2020

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