PropertyValue
?:abstract
  • A recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure upon SARS-CoV-2 infection. A new study2 comprising 3,199 hospitalized COVID-19 patients and controls finds that this is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neanderthals and is carried by ~50% of people in South Asia and ~16% of people in Europe today.
?:creator
?:doi
  • 10.1038/s41586-020-2818-3
?:doi
?:journal
  • Nature
?:license
  • cc-by
?:pmid
?:pmid
  • 32998156.0
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.
?:type
?:year
  • 2020-09-30

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