PropertyValue
?:abstract
  • The majority of SARS-CoV-2-infected individuals remain paucisymptomatic, contrasting with a minority of infected individuals in danger of death. Here, we speculate that the robust disease resistance of most individuals is due to a swift production of type I interferon (IFNα/β), presumably sufficient to lower the viremia. A minority of infected individuals with a preexisting chronic inflammatory state fail to mount this early efficient response, leading to a delayed harmful inflammatory response. To improve the epidemiological scenario, we propose combining: i) the development of efficient antivirals administered early enough to assist in the production of endogenous IFNα/β; ii) potentiating early IFN responses; iii) administering anti-inflammatory treatments when needed, but not too early to interfere with endogenous antiviral responses.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.it.2020.11.003
?:doi
?:journal
  • Trends_Immunol
?:license
  • els-covid
?:pdf_json_files
  • document_parses/pdf_json/005231044be54af2837fc45921b6fd92b04f04df.json
?:pmcid
?:pmid
?:pmid
  • 33281063.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Combining Antivirals and Immunomodulators to Fight COVID-19
?:type
?:year
  • 2020-11-13

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