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?:abstract
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Objective: We report the case of a young woman with postinfectious onset of myasthenia gravis after COVID-19 with mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department Methods: Patient data were derived from medical records of Hannover Medical School, Germany Written informed consent was obtained from the patient Results: The 21-year-old female patient presented with subacute, vertically shifted double vision evoked by right sided partial oculomotor paresis and ptosis About 4 weeks earlier she had suffered from mild respiratory symptoms, aching limbs and head without fever, accompanied by anosmia/ageusia During the persistence of the latter symptoms for around 10 days the patient had already noticed “tired eyes” and fluctuating double vision Clinical assessment including a positive test with edrophonium chloride and increased acetylcholine receptor antibodies related the ocular manifestation etiologically to myasthenia gravis Antibodies (IgA/IgG) against SARS-CoV-2 using three different serological tests (Abbott, DiaSorin, Euroimmun) were detected in serum suggesting this specific coronavirus as previously infectious agent in our patient The myasthenic syndrome was treated successfully with intravenous immunoglobulins and oral pyridostigmine Conclusion: This is the first case presentation of postinfectious myasthenia gravis as neurological complication in a COVID-19 patient
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