PropertyValue
?:abstract
  • OBJECTIVE: Multiple myeloma (MM) arises from malignant plasma cells as a single clone in the bone marrow. Accumulating evidences have reported that there is an association between miR-196a2 (rs11614913) variant and various cancers while there were unverified and inconsistent results in MM. The goal of this study is to investigate the impact of the miR-196a2 variant on clinical findings and susceptibility in MM. Two hundred MM patients (156 patients under transplantation of autologous stem cell) and 200 healthy controls included in this study. RESULTS: The statistical analysis showed no significant relationship for allele and frequencies of miR-196a2 genotype between patients and controls (p > 0.05). Log-rank test showed that gender has highly significant impact on both OS and PFS (p = 0.027, p = 0.045). In the univariate analysis, TT genotype (p = 0.022), and CT/TT (p = 0.008) had better OS. In the multivariate analysis, CC/CT-TT were associated with positively OS (p = 0.041). Currently, the most valuable prognostic markers in MM that has clinical implication are genetic abnormalities. It can be concluded from the results that miR-1962a variant is effective in prognosis of the MM. It is believed that these findings will help us understand the molecular basis of disease.
is ?:annotates of
?:creator
?:doi
  • 10.1186/s13104-020-05392-9
?:doi
?:journal
  • BMC_Res_Notes
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/942a4080f68813f03f2608f16bbc392fd8131e55.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7682760.xml.json
?:pmcid
?:pmid
?:pmid
  • 33228759.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • The miRNA 196a2 rs11614913 variant has prognostic impact on Turkish patients with multiple myeloma
?:type
?:year
  • 2020-11-23

Metadata

Anon_0  
expand all