PropertyValue
?:abstract
  • COVID-19 patients may exhibit neuropsychiatric and/or neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild or no respiratory symptoms and are associated with altered cerebral cortical thickness. Using an independent cohort, we found histopathological signs of brain damage in 19% of individuals who died of COVID-19. All of the affected brain tissues exhibited foci of SARS-CoV-2 infection, particularly in astrocytes. Infection of neural stem cell-derived astrocytes changed energy metabolism, altered key proteins and metabolites used to fuel neurons and for biogenesis of neurotransmitters, and elicited a secretory phenotype that reduces neuronal viability. Our data support the model where SARS-CoV-2 reaches the brain, infects astrocytes and triggers neuropathological changes that contribute to the structural and functional alterations in the brain of COVID-19 patients.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1101/2020.10.09.20207464
?:license
  • medrxiv
?:pdf_json_files
  • document_parses/pdf_json/f38d64dd4011b7531634ae73e88b975ebfb230d8.json
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • MedRxiv; WHO
?:title
  • SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability
?:type
?:year
  • 2020-10-13

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